INVESTIGATION OF THE IMMUNOMODULATOR EFFECT OF BETA GLUCAN IN THE EXPERIMENTAL INTRAABDOMINAL BACTERIEMIA MODEL WITH STAPHYLOCOCCUS AUREUS

OBJECTIVE: The purpose of this study is to investigate the immunomodulatory effect beta glucan in an experimental model intraabdominal bacteremia induced by S. aureus.MATERIAL AND METHODS: Thirty Wistar albino rats were randomly divided into four groups. Staphylococcus aureus (SAB), treatment with cefazolin, glucan, both cefazolin and groups constituted respectively. 4 mg/kg 100 given after 12x10 8 cfu/ml 1 cc was intraabdominally. After two hours, 0.5 blood drawn put culture bottles. Levels Tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), Interferon gamma (IFN-γ) evaluated 4th, 6th 8th hours.RESULTS: According biochemical analyses; At end it seen that increased level IFN-γ at hour, but did not 4th hours. This increase became more apparent 6 th hour when cefazolin. However levels found be higher group which than was. As serum TNF-α evaluated, although there a supression SAB group. Serum IL-1 hours Although decline detected added When IL-6 release first compared observed highest hour.CONCLUSIONS: intra-abdominal model, demonstrated supress production IL-1, IL- IFN-γ, especially these results, no significant knowledge could obtained about benefit using bacteremia.